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CarlaOliveiraLab
Laboratory of Post-Transcriptional Control of Gene Expression
![Institute of Chemistry](https://static.wixstatic.com/media/ce83bb_0cd263097dee4709aeaea7a022b657ef~mv2_d_6656_2982_s_4_2.jpg/v1/fill/w_980,h_439,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/ce83bb_0cd263097dee4709aeaea7a022b657ef~mv2_d_6656_2982_s_4_2.jpg)
Institute of Chemistry
![Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6](https://static.wixstatic.com/media/ce83bb_b6b0a2d9922c4a11b9c48c4fa96d70b7~mv2.jpg/v1/fill/w_649,h_414,al_c,q_80,enc_auto/ce83bb_b6b0a2d9922c4a11b9c48c4fa96d70b7~mv2.jpg)
Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6
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Institute of Chemistry
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The ribosome assembly factor Nop53 has a structural role in the formation of nuclear pre-60S intermediates, affecting late maturation events - Bagatelli et al., 2021. Nucleic acids research.
Crystal structure of the Pyrococcus abyssi exosome RNase PH complexed with a single-stranded 10-merpoly(A) RNA - Navarro et al., 2008. J Biol Chem.
The ribosome assembly factor Nop53 controls association of the RNA exosome with pre-60S particles in yeast - Cepeda et al., 2019. J Biol Chem.
This work was reported by the Department of Biochemistry from IQ-USP.
Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae - Gonzales-Zubiate et al., 2017. J Biol Chem.
This work was selected in this special JBC issue.
"Para a professora Carla Columbano de Oliveira, do Instituto de Química (IQ) da USP, não existe uma diferença clara entre o que é pesquisa básica e o que é pesquisa aplicada. Se um cientista não souber o que acontece na célula, argumenta ela, não há maneira de aplicar. E prossegue: 'é uma questão de tempo. Se eu não sei o que a proteína faz, como eu vou desenvolver um medicamento?'".
Publicado: 06/09/2013
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