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Crystal structure of the Pyrococcus abyssi exosome RNase PH complexed with a single-stranded 10-merpoly(A) RNA (Protein Data Bank code: 2po1; Navarro MVAS, Oliveira CC, Zanchin NIT, Guimaraes BG. 2008. Insights into the mechanism of progressive RNA degradation by the archaeal exosome. J Biol Chem 283: 14120–14131.
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The ribosome assembly factor Nop53 has a structural role in the formation of nuclear pre-60S intermediates, affecting late maturation events - Bagatelli et al., 2021. Nucleic acids research.

Crystal structure of the Pyrococcus abyssi exosome RNase PH complexed with a single-stranded 10-merpoly(A) RNA - Navarro et al., 2008. J Biol Chem.

The ribosome assembly factor Nop53 controls association of the RNA exosome with pre-60S particles in yeast - Cepeda et al., 2019. J Biol Chem.

This work was reported by the Department of Biochemistry from IQ-USP.

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Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae - Gonzales-Zubiate et al., 2017. J Biol Chem.  

 

This work was selected in this special JBC issue.

 

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"Para a professora Carla Columbano de Oliveira,  do Instituto de  Química (IQ) da USP, não  existe uma diferença clara entre o que é  pesquisa  básica e o que é pesquisa aplicada. Se  um  cientista não  souber o que acontece na  célula,  argumenta ela, não há maneira  de  aplicar. E prossegue: 'é uma questão de  tempo. Se eu não  sei  o que a proteína faz,  como eu vou  desenvolver um medicamento?'".

Publicado: 06/09/2013

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The research is financially supported by FAPESP, CNPq and CAPES grants.

 

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